CD134

TNFRSF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D0A, 2HEV, 2HEY
Identifiers
Aliases	TNFRSF4, ACT35, CD134, IMD16, OX40, TXGP1L, tumor necrosis factor receptor superfamily member 4, TNF receptor superfamily member 4
External IDs	OMIM: 600315 MGI: 104512 HomoloGene: 2496 GeneCards: TNFRSF4
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,214,153 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; upper lobe of left lung; ; blood; ; appendix; ; left ventricle; ; subcutaneous adipose tissue; ; right lung; ; right lobe of thyroid gland; ; left lobe of thyroid gland;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; tumor necrosis factor-activated receptor activity; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; cell surface; external side of plasma membrane;
Biological process	regulation of apoptotic process; tumor necrosis factor-mediated signaling pathway; negative regulation of DNA-binding transcription factor activity; multicellular organism development; T cell proliferation; response to lipopolysaccharide; regulation of cell population proliferation; positive regulation of B cell proliferation; immune response; apoptotic signaling pathway; viral entry into host cell; inflammatory response; negative regulation of transcription, DNA-templated; viral process; cellular defense response; regulation of protein kinase activity; negative regulation of activation-induced cell death of T cells; negative regulation of extrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7293
	22163
	ENSG00000186827
	n/a
	P43489
	P47741
	NM_003327
	NM_011659
	NP_003318
	NP_035789
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell; without CD28, expression of OX40 is delayed and of fourfold lower levels.

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