Interleukin-7 receptor-α

IL7R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DI2, 3DI3, 3UP1
Identifiers
Aliases	IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, Interleukin-7 receptor-α, interleukin 7 receptor
External IDs	OMIM: 146661 MGI: 96562 HomoloGene: 1646 GeneCards: IL7R
Gene location (Human)
Chr.	Chromosome 5 (human)
End	35,879,603 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	9,530,262 bp
RNA expression pattern
	Top expressed in
	right lung; ; lymph node; ; lower lobe of lung; ; appendix; ; blood; ; thymus; ; upper lobe of left lung; ; gallbladder; ; spleen; ; visceral pleura;
	Top expressed in
	blood; ; spleen; ; thymus; ; subcutaneous adipose tissue; ; bone marrow; ; Paneth cell; ; pharynx; ; carotid body; ; white adipose tissue; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antigen binding; interleukin-7 receptor activity; protein binding; cytokine receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; extracellular region; external side of plasma membrane; clathrin-coated vesicle membrane;
Biological process	regulation of cell size; regulation of DNA recombination; positive regulation of T cell differentiation in thymus; homeostasis of number of cells; negative regulation of T cell mediated cytotoxicity; cell surface receptor signaling pathway; B cell proliferation; T cell differentiation; positive regulation of gene expression; immune response; cell morphogenesis; lymph node development; immunoglobulin production; signal transduction; interleukin-7-mediated signaling pathway; positive regulation of cell population proliferation; positive regulation of receptor signaling pathway via STAT; membrane organization; negative regulation of T cell apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	3575
	16197
	ENSG00000168685
	ENSMUSG00000003882
	P16871
	P16872
	NM_002185
	NM_008372; NM_001355680
	NP_002176
	NP_032398; NP_001342609
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene.

IL7R-α is a type I cytokine receptor and is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors.

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