Interleukin 1 receptor, type I

IL1R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1G0Y, 1IRA, 1ITB, 4DEP, 4GAF
Identifiers
Aliases	IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80, Interleukin 1 receptor, type I, interleukin 1 receptor type 1
External IDs	OMIM: 147810 MGI: 96545 HomoloGene: 677 GeneCards: IL1R1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	102,179,874 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	40,317,257 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; tibia; ; pericardium; ; corpus epididymis; ; caput epididymis; ; urethra; ; vena cava; ; visceral pleura; ; parietal pleura; ; germinal epithelium;
	Top expressed in
	islet of Langerhans; ; seminal vesicula; ; belly cord; ; medullary collecting duct; ; aortic valve; ; ciliary body; ; cumulus cell; ; secondary oocyte; ; hair follicle; ; lacrimal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-1, type I, activating receptor activity; signal transducer activity; platelet-derived growth factor receptor binding; protease binding; protein binding; transmembrane signaling receptor activity; interleukin-1 receptor activity; interleukin-1 binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; external side of plasma membrane;
Biological process	cell surface receptor signaling pathway; immune response; regulation of inflammatory response; signal transduction; positive regulation of interleukin-1-mediated signaling pathway; positive regulation of neutrophil extravasation; response to interleukin-1; cytokine-mediated signaling pathway; interleukin-1-mediated signaling pathway; positive regulation of interferon-gamma production; positive regulation of T-helper 1 cell cytokine production; inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	3554
	16177
	ENSG00000115594
	ENSMUSG00000026072
	P14778
	P13504
NM_000877; NM_001288706; NM_001320978; NM_001320980; NM_001320981;
	NM_001320982; NM_001320983; NM_001320984; NM_001320985; NM_001320986
	NM_001123382; NM_008362
NP_000868; NP_001275635; NP_001307907; NP_001307909; NP_001307910;
	NP_001307911; NP_001307912; NP_001307913; NP_001307914; NP_001307915
	NP_001116854; NP_032388
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.

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