Integrin alpha X

ITGAX
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1N3Y, 2LUV, 3K6S, 3K71, 3K72, 4NEH, 4NEN, 5ES4
Identifiers
Aliases	ITGAX, CD11C, SLEB6, integrin subunit alpha X
External IDs	OMIM: 151510 MGI: 96609 HomoloGene: 55493 GeneCards: ITGAX
Gene location (Human)
Chr.	Chromosome 16 (human)
End	31,382,999 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	127,749,829 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; upper lobe of left lung; ; spleen; ; right lung; ; appendix; ; gallbladder; ; bone marrow cells; ; lymph node; ; left uterine tube;
	Top expressed in
	spleen; ; right lung lobe; ; blood; ; jejunum; ; thymus; ; subcutaneous adipose tissue; ; ileum; ; duodenum; ; carotid body; ; calvaria;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; signaling receptor activity;
Cellular component	integral component of membrane; cell surface; integrin complex; plasma membrane; membrane; secretory granule membrane; tertiary granule membrane; ficolin-1-rich granule membrane;
Biological process	animal organ morphogenesis; integrin-mediated signaling pathway; heterotypic cell-cell adhesion; cell adhesion; extracellular matrix organization; leukocyte migration; positive regulation of protein targeting to mitochondrion; neutrophil degranulation; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3687
	16411
	ENSG00000140678
	ENSMUSG00000030789
	P20702
	Q9QXH4
	NM_000887; NM_001286375
	NM_021334; NM_001363984; NM_001363985
	NP_000878; NP_001273304
	NP_067309; NP_001350913; NP_001350914
	Wikidata
View/Edit Human	View/Edit Mouse

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c .

CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.

CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

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