Poliovirus receptor-related 1

NECTIN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ALP, 3SKU, 3U83, 4FMF, 4MYW
Identifiers
Aliases	NECTIN1, CD111, CLPED1, ED4, HIgR, HV1S, HVEC, OFC7, PRR, PRR1, PVRR, PVRR1, SK-12, nectin-1, PVRL1, nectin cell adhesion molecule 1
External IDs	OMIM: 600644 MGI: 1926483 HomoloGene: 2138 GeneCards: NECTIN1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	119,729,200 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	43,743,955 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; nipple; ; body of tongue; ; subthalamic nucleus; ; vulva; ; external globus pallidus; ; vena cava; ; inferior ganglion of vagus nerve; ; prefrontal cortex; ; superior surface of tongue;
	Top expressed in
	lip; ; molar; ; visual cortex; ; cerebellar cortex; ; stellate reticulum; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; inferior colliculus; ; subiculum; ; piriform cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; coreceptor activity; virus receptor activity; protein binding; protein heterodimerization activity; virion binding; signaling receptor binding; carbohydrate binding; cell adhesion molecule binding; identical protein binding; signaling receptor activity;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; plasma membrane; growth cone membrane; synapse; integral component of plasma membrane; extracellular region; axon; cell junction; neuron projection; catenin complex; presynaptic membrane; apical junction complex; cell-cell contact zone; cell-cell junction; adherens junction; dendrite; hippocampal mossy fiber to CA3 synapse; integral component of presynaptic active zone membrane;
Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; cell recognition; desmosome organization; regulation of synapse assembly; axon guidance; cell adhesion; iron ion transport; lens morphogenesis in camera-type eye; retina development in camera-type eye; immune response; viral entry into host cell; enamel mineralization; viral process; adherens junction organization; camera-type eye morphogenesis; homophilic cell adhesion via plasma membrane adhesion molecules; signal transduction; protein localization to cell junction; cell-cell adhesion; virion attachment to host cell;
	Sources:Amigo / QuickGO
Orthologs
	5818
	58235
	ENSG00000110400
	ENSMUSG00000032012
	Q15223
	Q9JKF6
	NM_203286; NM_002855; NM_032767; NM_203285
	NM_021424
	NP_002846; NP_976030; NP_976031
	NP_067399
	Wikidata
View/Edit Human	View/Edit Mouse

Poliovirus receptor-related 1 (PVRL1), also known as nectin-1 and CD111 (formerly herpesvirus entry mediator C, HVEC) is a human protein of the immunoglobulin superfamily (IgSF), also considered a member of the nectins. It is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail. The protein can mediate Ca²⁺-independent cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM).

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