Thrombopoietin receptor

MPL
Identifiers
Aliases	MPL, C-CD110, MPLV, THCYT2, TPOR, MPL proto-oncogene, thrombopoietin receptor, THPOR
External IDs	OMIM: 159530 MGI: 97076 HomoloGene: 7845 GeneCards: MPL
Gene location (Human)
Chr.	Chromosome 1 (human)
End	43,354,466 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	118,314,710 bp
RNA expression pattern
	Top expressed in
	monocyte; ; bone marrow cells; ; bronchial epithelial cell; ; sural nerve; ; Brodmann area 9; ; prefrontal cortex; ; left ventricle; ; blood; ; cingulate gyrus; ; right coronary artery;
	Top expressed in
	blood; ; morula; ; yolk sac; ; spleen; ; bone marrow; ; body of femur; ; abdominal wall; ; trachea; ; thorax; ; cochlea;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; protein binding; transmembrane signaling receptor activity; thrombopoietin receptor activity;
Cellular component	integral component of membrane; cell surface; Golgi apparatus; integral component of plasma membrane; membrane; plasma membrane; neuron projection; neuronal cell body;
Biological process	cell surface receptor signaling pathway; cell population proliferation; cytokine-mediated signaling pathway; thrombopoietin-mediated signaling pathway; neutrophil homeostasis; monocyte homeostasis; positive regulation of lymphocyte proliferation; platelet aggregation; cellular response to hypoxia; positive regulation of platelet formation; eosinophil homeostasis; basophil homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	4352
	17480
	ENSG00000117400
	ENSMUSG00000006389
	P40238
	Q08351
	NM_005373
	NM_001122949; NM_001285496; NM_001285497; NM_010823
	NP_005364
	NP_001116421; NP_001272425; NP_001272426; NP_034953
	Wikidata
View/Edit Human	View/Edit Mouse

The thrombopoietin receptor also known as the myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110) is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene.

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