LAMP2

LAMP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MOF, 2MOM
Identifiers
Aliases	LAMP2, CD107b, LAMP-2, LAMPB, LGP110, lysosomal associated membrane protein 2, LGP-96, DND
External IDs	OMIM: 309060 MGI: 96748 HomoloGene: 7809 GeneCards: LAMP2
Gene location (Human)
Chr.	X chromosome (human)
End	120,469,365 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	37,545,331 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; external globus pallidus; ; kidney tubule; ; parotid gland; ; gallbladder; ; inferior ganglion of vagus nerve; ; stromal cell of endometrium; ; subthalamic nucleus; ; optic nerve; ; islet of Langerhans;
	Top expressed in
	ciliary body; ; iris; ; conjunctival fornix; ; aortic valve; ; hair follicle; ; molar; ; left lung lobe; ; proximal tubule; ; ascending aorta; ; cornea;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; protein binding; enzyme binding;
Cellular component	integral component of membrane; membrane microdomain; endosome; late endosome; phagocytic vesicle membrane; chaperone-mediated autophagy translocation complex; membrane; late endosome membrane; plasma membrane; lysosomal membrane; lysosomal lumen; platelet dense granule membrane; lysosome; endosome membrane; extracellular exosome; autophagosome membrane; extracellular space; trans-Golgi network; cytoplasmic vesicle; azurophil granule membrane; autolysosome; perinuclear region of cytoplasm; integral component of autophagosome membrane; ficolin-1-rich granule membrane; membrane raft; lysosomal matrix;
Biological process	regulation of protein stability; muscle cell cellular homeostasis; protein stabilization; platelet degranulation; protein import; protein targeting; autophagy; cellular response to starvation; negative regulation of protein homooligomerization; neutrophil degranulation; chaperone-mediated autophagy; protein targeting to lysosome involved in chaperone-mediated autophagy; autophagosome maturation; lysosomal protein catabolic process; establishment of protein localization to organelle;
	Sources:Amigo / QuickGO
Orthologs
	3920
	16784
	ENSG00000005893
	ENSMUSG00000016534
	P13473
	P17047
	NM_013995; NM_001122606; NM_002294
	NM_001017959; NM_001290485; NM_010685
	NP_001116078; NP_002285; NP_054701
	NP_001017959; NP_001277414; NP_034815
	Wikidata
View/Edit Human	View/Edit Mouse

Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins.

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of the gene produces three variants - LAMP-2A, LAMP-2B and LAMP-2C. LAMP-2A is the receptor for chaperone-mediated autophagy. Recently it has been determined that antibodies against LAMP-2 account for a fraction of patients who get a serious kidney disease termed focal necrotizing glomerulonephritis.

LAMP-2B is associated with Danon disease.

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