SEMA4D

SEMA4D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OLZ, 3OL2
Identifiers
Aliases	SEMA4D, C9orf164, CD100, M-sema-G, SEMAJ, coll-4, semaphorin 4D, COLL4, A8, GR3, BB18
External IDs	OMIM: 601866 MGI: 109244 HomoloGene: 21282 GeneCards: SEMA4D
Gene location (Human)
Chr.	Chromosome 9 (human)
End	89,498,130 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	51,793,747 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; blood; ; monocyte; ; inferior ganglion of vagus nerve; ; lymph node; ; internal globus pallidus; ; substantia nigra; ; spleen; ; gastrocnemius muscle; ; subthalamic nucleus;
	Top expressed in
	thymus; ; cumulus cell; ; blood; ; spleen; ; submandibular gland; ; proximal tubule; ; molar; ; corpus callosum; ; cerebellar cortex; ; kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; transmembrane signaling receptor activity; protein binding; semaphorin receptor binding; neuropilin binding; identical protein binding; signaling receptor activity; chemorepellent activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; extracellular space;
Biological process	regulation of dendrite morphogenesis; negative regulation of apoptotic process; positive regulation of phosphatidylinositol 3-kinase signaling; multicellular organism development; leukocyte aggregation; nervous system development; negative regulation of cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of axonogenesis; semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis; regulation of cell projection organization; negative regulation of osteoblast differentiation; positive regulation of collateral sprouting; regulation of cell shape; negative regulation of peptidyl-tyrosine phosphorylation; cell differentiation; positive regulation of protein phosphorylation; semaphorin-plexin signaling pathway; cell adhesion; immune response; ossification involved in bone maturation; positive regulation of cell migration; negative regulation of transcription by RNA polymerase II; positive regulation of GTPase activity; negative regulation of alkaline phosphatase activity; negative chemotaxis; neural crest cell migration; negative regulation of axon extension involved in axon guidance; positive regulation of inhibitory synapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	10507
	20354
	ENSG00000187764
	ENSMUSG00000021451
	Q92854
	O09126
NM_001142287; NM_006378; NM_182635; NM_001371194; NM_001371195;
	NM_001371196; NM_001371197; NM_001371198; NM_001371199; NM_001371200; NM_001371201; NM_001371202
	NM_001281880; NM_013660
NP_001135759; NP_006369; NP_001358123; NP_001358124; NP_001358125;
	NP_001358126; NP_001358127; NP_001358128; NP_001358129; NP_001358130; NP_001358131
NP_001268809; NP_038688; NP_001365242; NP_001365243; NP_001365246;
	NP_001365247; NP_001365248; NP_001365249; NP_001365251; NP_001365252; NP_001365253; NP_001365244; NP_001365245; NP_001365250; NP_001365254
	Wikidata
View/Edit Human	View/Edit Mouse

Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.

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