CCL2

CCL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 4DN4, 3IFD, 4R8I, 4ZK9
Identifiers
Aliases	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2
External IDs	OMIM: 158105 MGI: 108224 HomoloGene: 2245 GeneCards: CCL2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	34,257,208 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	81,994,226 bp
RNA expression pattern
	Top expressed in
	vena cava; ; gallbladder; ; islet of Langerhans; ; gastric mucosa; ; rectum; ; left uterine tube; ; smooth muscle tissue; ; saphenous vein; ; right ventricle; ; right coronary artery;
	Top expressed in
	cervix; ; thymus; ; subcutaneous adipose tissue; ; aortic valve; ; dermis; ; white adipose tissue; ; lip; ; zone of skin; ; optic nerve; ; mammary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; protein kinase activity; cytokine activity; protein binding; chemokine activity; CCR2 chemokine receptor binding; CCR chemokine receptor binding;
Cellular component	extracellular region; extracellular space; intracellular anatomical structure;
Biological process	negative regulation of neuron apoptotic process; viral genome replication; negative regulation of natural killer cell chemotaxis; protein phosphorylation; cell surface receptor signaling pathway; humoral immune response; angiogenesis; positive regulation of ERK1 and ERK2 cascade; animal organ morphogenesis; cellular homeostasis; cellular response to fibroblast growth factor stimulus; positive regulation of GTPase activity; inflammatory response; G protein-coupled receptor signaling pathway; monocyte chemotaxis; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; cellular response to organic cyclic compound; chemotaxis; cell adhesion; immune response; regulation of cell shape; lipopolysaccharide-mediated signaling pathway; receptor signaling pathway via JAK-STAT; response to bacterium; protein kinase B signaling; astrocyte cell migration; negative regulation of glial cell apoptotic process; PERK-mediated unfolded protein response; MAPK cascade; positive regulation of calcium ion import; cytoskeleton organization; signal transduction; regulation of signaling receptor activity; neutrophil chemotaxis; helper T cell extravasation; macrophage chemotaxis; positive regulation of T cell activation; positive regulation of nitric-oxide synthase biosynthetic process; chemokine-mediated signaling pathway; cellular response to lipopolysaccharide; cellular response to interferon-gamma; cellular response to interleukin-1; cellular response to tumor necrosis factor; positive regulation of apoptotic cell clearance; cytokine-mediated signaling pathway; negative regulation of vascular endothelial cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; positive regulation of endothelial cell apoptotic process; eosinophil chemotaxis; lymphocyte chemotaxis; sensory perception of pain; positive regulation of synaptic transmission, glutamatergic; positive regulation of NMDA glutamate receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	6347
	20293
	ENSG00000108691
	ENSMUSG00000035352
	P13500
	Q62401
	NM_002982
	NM_011331
	NP_002973
	NP_035461
	Wikidata
View/Edit Human	View/Edit Mouse

The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 tightly regulates cellular mechanics and thereby recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection.

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