Cannabinoid receptor 2

CNR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KI9
Identifiers
Aliases	CNR2, CB-2, CB2, CX5, Cannabinoid receptor type 2, cannabinoid receptor 2
External IDs	OMIM: 605051 MGI: 104650 HomoloGene: 1389 GeneCards: CNR2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	23,913,362 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	135,647,518 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; tibialis anterior muscle; ; deltoid muscle; ; blood; ; cecum; ; appendix; ; superior surface of tongue; ; thymus; ; bone marrow;
	Top expressed in
	spleen; ; blood; ; subcutaneous adipose tissue; ; thymus; ; right lung lobe; ; left colon; ; calvaria; ; left lobe of liver; ; spermatocyte; ; mammary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; cannabinoid receptor activity;
Cellular component	integral component of membrane; perikaryon; cell projection; membrane; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; integral component of plasma membrane; neuronal cell body; dendrite; neuron projection;
Biological process	negative regulation of nitric-oxide synthase activity; negative regulation of mast cell activation; cannabinoid signaling pathway; response to amphetamine; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; negative regulation of action potential; response to lipopolysaccharide; negative regulation of synaptic transmission, GABAergic; immune response; sensory perception of pain; inflammatory response; negative regulation of inflammatory response; signal transduction; leukocyte chemotaxis; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1269
	12802
	ENSG00000188822
	ENSMUSG00000062585
	P34972
	P47936
	NM_001841
	NM_009924; NM_001305278
	NP_001832
	NP_001292207; NP_034054
	Wikidata
View/Edit Human	View/Edit Mouse

The cannabinoid receptor 2 (CB2), is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene. It is closely related to the cannabinoid receptor 1 (CB1), which is largely responsible for the efficacy of endocannabinoid-mediated presynaptic-inhibition, the psychoactive properties of tetrahydrocannabinol (THC), the active agent in cannabis, and other phytocannabinoids (plant cannabinoids). The principal endogenous ligand for the CB2 receptor is 2-Arachidonoylglycerol (2-AG).

CB2 was cloned in 1993 by a research group from Cambridge looking for a second cannabinoid receptor that could explain the pharmacological properties of tetrahydrocannabinol. The receptor was identified among cDNAs based on its similarity in amino-acid sequence to the cannabinoid receptor 1 (CB1) receptor, discovered in 1990. The discovery of this receptor helped provide a molecular explanation for the established effects of cannabinoids on the immune system.

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