Cannabinoid receptor 1

CNR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LVQ, 1LVR, 2B0Y, 2KOE, 2MZ3, 2MZ2, 2MZA,%%s1LVQ, 1LVR, 2B0Y, 2KOE
Identifiers
Aliases	CNR1, CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, cannabinoid receptor 1 (brain), cannabinoid receptor 1, cannabinoid CB1 receptor gene
External IDs	OMIM: 114610 MGI: 104615 HomoloGene: 7273 GeneCards: CNR1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	88,166,347 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	33,948,831 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; cerebellar vermis; ; frontal pole; ; Region I of hippocampus proper; ; Brodmann area 10; ; Brodmann area 23; ; endothelial cell; ; middle frontal gyrus; ; pericardium; ; middle temporal gyrus;
	Top expressed in
	cerebellar vermis; ; subiculum; ; ventromedial nucleus; ; lateral hypothalamus; ; superior frontal gyrus; ; dorsomedial hypothalamic nucleus; ; globus pallidus; ; habenula; ; nucleus accumbens; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; cannabinoid receptor activity; protein binding; voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels;
Cellular component	integral component of membrane; intracellular membrane-bounded organelle; membrane; growth cone; integral component of plasma membrane; axon; membrane raft; plasma membrane; presynaptic membrane; mitochondrion; mitochondrial outer membrane; cell projection; integral component of mitochondrial membrane; presynapse; glutamatergic synapse; GABA-ergic synapse; integral component of presynaptic membrane;
Biological process	negative regulation of nitric-oxide synthase activity; negative regulation of mast cell activation; glucose homeostasis; response to nutrient; regulation of insulin secretion; negative regulation of blood pressure; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; maternal process involved in female pregnancy; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; response to nicotine; human ageing; positive regulation of fever generation; memory; negative regulation of action potential; regulation of feeding behavior; negative regulation of ion transport; response to morphine; negative regulation of fatty acid beta-oxidation; response to lipopolysaccharide; positive regulation of blood pressure; regulation of penile erection; regulation of lipid metabolic process; spermatogenesis; positive regulation of neuron projection development; positive regulation of apoptotic process; positive regulation of acute inflammatory response to antigenic stimulus; learning or memory; sensory perception of pain; negative regulation of dopamine secretion; regulation of synaptic transmission, glutamatergic; response to ethanol; axonal fasciculation; regulation of synaptic transmission, GABAergic; signal transduction; response to cocaine; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission; G protein-coupled receptor signaling pathway; cannabinoid signaling pathway; retrograde trans-synaptic signaling by endocannabinoid; positive regulation of presynaptic cytosolic calcium concentration; induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	1268
	12801
	ENSG00000118432
	ENSMUSG00000044288
	P21554
	P47746
NM_001160226; NM_001160258; NM_001160259; NM_001160260; NM_016083;
	NM_033181; NM_001365869; NM_001365870; NM_001365872; NM_001365874; NM_001370545; NM_001370546; NM_001370547
	NM_007726; NM_001355020; NM_001355021; NM_001365881
NP_001153698; NP_001153730; NP_001153731; NP_057167; NP_149421;
	NP_001352798; NP_001352799; NP_001352801; NP_001352803; NP_001357474; NP_001357475; NP_001357476
	NP_031752; NP_001341949; NP_001341950; NP_001352810
	Wikidata
View/Edit Human	View/Edit Mouse

Cannabinoid receptor 1 (CB1), is a G protein-coupled cannabinoid receptor that in humans is encoded by the CNR1 gene. The human CB1 receptor is expressed in the peripheral nervous system and central nervous system. It is activated by endocannabinoids, a group of retrograde neurotransmitters that include anandamide and 2-arachidonoylglycerol (2-AG); plant phytocannabinoids, such as docosatetraenoylethanolamide found in wild daga, the compound THC which is an active constituent of the psychoactive drug cannabis; and synthetic analogs of THC. CB1 is antagonized by the phytocannabinoid tetrahydrocannabivarin (THCV).

The primary endogenous agonist of the human CB1 receptor is anandamide.

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