C-reactive protein

CRP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B09, 1GNH, 1LJ7, 3L2Y, 3PVN, 3PVO
Identifiers
Aliases	CRP, PTX1, C-reactive protein, pentraxin-related, C-Reactive Protein
External IDs	OMIM: 123260 MGI: 88512 HomoloGene: 128039 GeneCards: CRP
Gene location (Human)
Chr.	Chromosome 1 (human)
End	159,714,589 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	172,660,598 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; islet of Langerhans; ; gallbladder; ; body of pancreas; ; pancreatic epithelial cell; ; right coronary artery; ; pancreatic ductal cell; ; canal of the cervix; ; right lung; ; gastric mucosa;
	Top expressed in
	left lobe of liver; ; sexually immature organism; ; vas deferens; ; thymus; ; epididymis; ; digastric muscle; ; pancreas; ; duodenum; ; uterus; ; islet of Langerhans;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	low-density lipoprotein particle receptor binding; calcium ion binding; virion binding; complement component C1q complex binding; protein binding; metal ion binding; low-density lipoprotein particle binding; choline binding; identical protein binding;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of lipid storage; positive regulation of superoxide anion generation; positive regulation of gene expression; inflammatory response; acute-phase response; negative regulation of macrophage derived foam cell differentiation; opsonization; defense response to Gram-positive bacterium; complement activation, classical pathway; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	1401
	12944
	ENSG00000132693
	ENSMUSG00000037942
	P02741
	P14847
	NM_000567; NM_001329057; NM_001329058; NM_001382703
	NM_007768
	NP_000558; NP_001315986; NP_001315987; NP_001369632
	NP_031794
	Wikidata
View/Edit Human	View/Edit Mouse

C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells. Its physiological role is to bind to lysophosphatidylcholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system via C1q.

CRP is synthesized by the liver in response to factors released by macrophages, T cells and fat cells (adipocytes). It is a member of the pentraxin family of proteins. It is not related to C-peptide (insulin) or protein C (blood coagulation). C-reactive protein was the first pattern recognition receptor (PRR) to be identified.

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