BUB1B

BUB1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WVI, 3SI5, 4GGD, 5JJA
Identifiers
Aliases	BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B
External IDs	OMIM: 602860 MGI: 1333889 HomoloGene: 933 GeneCards: BUB1B
Gene location (Human)
Chr.	Chromosome 15 (human)
End	40,221,123 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	118,472,072 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; embryo; ; ganglionic eminence; ; bone marrow; ; spongy bone; ; bone marrow cells; ; thymus; ; rectum; ; appendix; ; stromal cell of endometrium;
	Top expressed in
	secondary oocyte; ; ectoderm; ; primitive streak; ; otic placode; ; spermatocyte; ; maxillary prominence; ; hand; ; spermatid; ; abdominal wall; ; somite;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase activity; ATP binding; protein binding; kinase activity; nucleotide binding; transferase activity; protein kinase activity;
Cellular component	kinetochore; nucleus; cytoskeleton; outer kinetochore; microtubule organizing center; perinuclear region of cytoplasm; chromosome, centromeric region; anaphase-promoting complex; chromosome; cytoplasm; spindle midzone; cytosol; spindle;
Biological process	protein localization to chromosome, centromeric region; anaphase-promoting complex-dependent catabolic process; mitotic cell cycle checkpoint signaling; protein phosphorylation; metaphase; cell cycle; apoptotic process; phosphorylation; cell division; cell population proliferation; protein localization to kinetochore; mitotic spindle assembly checkpoint signaling; meiotic sister chromatid cohesion, centromeric; mitotic cell cycle; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	701
	12236
	ENSG00000156970
	ENSMUSG00000040084
	O60566
	Q9Z1S0
	NM_001211
	NM_009773
	NP_001202
	NP_033903
	Wikidata
View/Edit Human	View/Edit Mouse

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene. Also known as BubR1, this protein is recognized for its mitotic roles in the spindle assembly checkpoint (SAC) and kinetochore-microtubule interactions that facilitate chromosome migration and alignment. BubR1 promotes mitotic fidelity and protects against aneuploidy by ensuring proper chromosome segregation between daughter cells. BubR1 is proposed to prevent tumorigenesis.

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