Beta-2 adrenergic receptor

ADRB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4QKX, 2R4R, 2R4S, 2RH1, 3D4S, 3KJ6, 3NY8, 3NY9, 3NYA, 3P0G, 3PDS, 3SN6, 4GBR, 4LDE, 4LDL, 4LDO, 5D5A, 5D5B, 5JQH
Identifiers
Aliases	ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR, adrenoceptor beta 2
External IDs	OMIM: 109690 MGI: 87938 HomoloGene: 30948 GeneCards: ADRB2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	148,828,623 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	62,313,030 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; skin of abdomen; ; lower lobe of lung; ; right lung; ; subcutaneous adipose tissue; ; upper lobe of left lung; ; blood; ; monocyte; ; bone marrow; ; nipple;
	Top expressed in
	corneal stroma; ; left lung lobe; ; right lung; ; right lung lobe; ; intercostal muscle; ; blood; ; spleen; ; thoracic diaphragm; ; soleus muscle; ; plantaris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	adenylate cyclase binding; adrenergic receptor activity; beta2-adrenergic receptor activity; enzyme binding; protein homodimerization activity; potassium channel regulator activity; protein binding; G protein-coupled receptor activity; signal transducer activity; norepinephrine binding; epinephrine binding; amyloid-beta binding; protein-containing complex binding;
Cellular component	endosome; membrane; nucleus; apical plasma membrane; lysosome; integral component of membrane; receptor complex; plasma membrane; early endosome; integral component of plasma membrane; endosome membrane; clathrin-coated vesicle membrane;
Biological process	positive regulation of autophagosome maturation; adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of sodium ion transport; endosome to lysosome transport; receptor-mediated endocytosis; cell surface receptor signaling pathway; regulation of systemic arterial blood pressure by norepinephrine-epinephrine; negative regulation of smooth muscle contraction; regulation of smooth muscle contraction; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; bone resorption; adenylate cyclase-activating adrenergic receptor signaling pathway; heat generation; desensitization of G protein-coupled receptor signaling pathway by arrestin; positive regulation of MAPK cascade; G protein-coupled receptor signaling pathway; positive regulation of bone mineralization; activation of adenylate cyclase activity; brown fat cell differentiation; activation of transmembrane receptor protein tyrosine kinase activity; positive regulation of protein ubiquitination; negative regulation of multicellular organism growth; cell-cell signaling; diet induced thermogenesis; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of lipophagy; response to cold; positive regulation of transcription by RNA polymerase II; signal transduction; protein deubiquitination; membrane organization; adrenergic receptor signaling pathway; blood vessel diameter maintenance; positive regulation of protein kinase A signaling; positive regulation of mini excitatory postsynaptic potential; positive regulation of protein serine/threonine kinase activity; positive regulation of cold-induced thermogenesis; cellular response to amyloid-beta; response to psychosocial stress; positive regulation of cAMP-dependent protein kinase activity; positive regulation of AMPA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	154
	11555
	ENSG00000169252
	ENSMUSG00000045730
	P07550
	P18762
	NM_000024
	NM_007420
	NP_000015
	NP_031446
	Wikidata
View/Edit Human	View/Edit Mouse

The beta-2 adrenergic receptor (β₂ adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that binds epinephrine (adrenaline), a hormone and neurotransmitter whose signaling, via adenylate cyclase stimulation through trimeric G_s proteins, increases cAMP, and, via downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation.

Robert J. Lefkowitz and Brian Kobilka studied beta 2 adrenergic receptor as a model system which rewarded them the 2012 Nobel Prize in Chemistry “for groundbreaking discoveries that reveal the inner workings of an important family of such receptors: G-protein-coupled-receptors”.

The official symbol for the human gene encoding the β₂ adrenoreceptor is ADRB2.

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