Beta-1 adrenergic receptor

ADRB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LSQ
Identifiers
Aliases	ADRB1, ADRB1R, B1AR, BETA1AR, RHR, adrenoceptor beta 1, FNSS2
External IDs	OMIM: 109630 MGI: 87937 HomoloGene: 20171 GeneCards: ADRB1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	114,046,904 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	56,721,545 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; parotid gland; ; bronchial epithelial cell; ; lower lobe of lung; ; endothelial cell; ; placenta; ; Brodmann area 23; ; postcentral gyrus; ; entorhinal cortex; ; left ventricle;
	Top expressed in
	parotid gland; ; pineal gland; ; right lung; ; right lung lobe; ; submandibular gland; ; left lung; ; primary motor cortex; ; prefrontal cortex; ; nucleus accumbens; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	beta-adrenergic receptor activity; PDZ domain binding; G protein-coupled receptor activity; epinephrine binding; norepinephrine binding; signal transducer activity; adrenergic receptor activity; protein binding; alpha-2A adrenergic receptor binding; protein heterodimerization activity; beta1-adrenergic receptor activity; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; endosome; membrane; plasma membrane; integral component of plasma membrane; early endosome; Schaffer collateral - CA1 synapse; integral component of postsynaptic density membrane;
Biological process	fear response; adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of multicellular organism growth; cell-cell signaling; positive regulation of cAMP-mediated signaling; positive regulation of heart rate by epinephrine-norepinephrine; activation of adenylate cyclase activity; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure; diet induced thermogenesis; adenylate cyclase-activating adrenergic receptor signaling pathway; positive regulation of heart contraction; positive regulation of GTPase activity; positive regulation of the force of heart contraction by epinephrine-norepinephrine; heat generation; brown fat cell differentiation; response to cold; temperature homeostasis; signal transduction; G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; regulation of postsynaptic membrane potential; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	153
	11554
	ENSG00000043591
	ENSMUSG00000035283
	P08588
	P34971
	NM_000684
	NM_007419
	NP_000675
	NP_031445
	Wikidata
View/Edit Human	View/Edit Mouse

The beta-1 adrenergic receptor (β₁ adrenoceptor), also known as ADRB1, can refer to either the protein-encoding gene (gene ADRB1) or one of the four adrenergic receptors. It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein that is expressed predominantly in cardiac tissue. In addition to cardiac tissue, beta-1 adrenergic receptors are also expressed in the cerebral cortex.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.