Bcl-2 family
The Bcl-2 family (TC# 1.A.21) consists of a number of evolutionarily-conserved proteins that share Bcl-2 homology (BH) domains. The Bcl-2 family is most notable for their regulation of apoptosis, a form of programmed cell death, at the mitochondrion. The Bcl-2 family proteins consists of members that either promote or inhibit apoptosis, and control apoptosis by governing mitochondrial outer membrane permeabilization (MOMP), which is a key step in the intrinsic pathway of apoptosis. A total of 25 genes in the Bcl-2 family were identified by 2008.
| Apoptosis regulator proteins, Bcl-2 family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Structure of human Bcl-xL, an inhibitor of programmed cell death. | |||||||||
| Identifiers | |||||||||
| Symbol | Bcl-2 | ||||||||
| Pfam | PF00452 | ||||||||
| InterPro | IPR002475 | ||||||||
| SMART | SM00337 | ||||||||
| PROSITE | PDOC00829 | ||||||||
| SCOP2 | 1maz / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 40 | ||||||||
| OPM protein | 2l5b | ||||||||
| Membranome | 232 | ||||||||
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