B-cell activating factor

TNFSF13B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JH5, 1KD7, 1KXG, 1OQD, 1OQE, 1OSG, 3V56, 4V46, 4ZCH
Identifiers
Aliases	TNFSF13B, BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, ZTNF4, TNLG7A, tumor necrosis factor superfamily member 13b, TNF superfamily member 13b
External IDs	OMIM: 603969 MGI: 1344376 HomoloGene: 48443 GeneCards: TNFSF13B
Gene location (Human)
Chr.	Chromosome 13 (human)
End	108,308,484 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	10,089,072 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; spongy bone; ; bone marrow; ; appendix; ; germinal epithelium; ; pancreatic epithelial cell; ; lymph node; ; parietal pleura; ; visceral pleura;
	Top expressed in
	morula; ; vas deferens; ; secondary oocyte; ; right lung lobe; ; intestinal villus; ; urethra; ; female urethra; ; male urethra; ; duodenum; ; carotid body;
	More reference expression data
	n/a
Gene ontology
Molecular function	tumor necrosis factor receptor binding; cytokine activity; signaling receptor binding; protein binding;
Cellular component	cytoplasm; integral component of membrane; perinuclear region of cytoplasm; extracellular region; plasma membrane; membrane; extracellular space;
Biological process	cell population proliferation; tumor necrosis factor-mediated signaling pathway; immune response; signal transduction; positive regulation of cell population proliferation; immune system process; regulation of immune response; T cell costimulation; B cell homeostasis; B cell costimulation; positive regulation of T cell proliferation; positive regulation of B cell proliferation; positive regulation of germinal center formation; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	10673
	24099
	ENSG00000102524
	ENSMUSG00000031497
	Q9Y275
	Q9WU72
	NM_001145645; NM_006573
	NM_033622; NM_001347309
	NP_001139117; NP_006564
	NP_001334238; NP_296371
	Wikidata
View/Edit Human	View/Edit Mouse

B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, is a protein that in humans is encoded by the TNFSF13B gene. BAFF is also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and the Dendritic cell-derived TNF-like molecule (CD257 antigen; cluster of differentiation 257).

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