Atropine
Atropine is a tropane alkaloid and anticholinergic medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery. It is typically given intravenously or by injection into a muscle. Eye drops are also available which are used to treat uveitis and early amblyopia. The intravenous solution usually begins working within a minute and lasts half an hour to an hour. Large doses may be required to treat some poisonings.
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| Trade names | Atropen, others |
| Other names | Daturin |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682487 |
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| Routes of administration | By mouth, intravenous, intramuscular, rectal, ophthalmic |
| Drug class | antimuscarinic (anticholinergic) |
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| Pharmacokinetic data | |
| Bioavailability | 25% |
| Metabolism | ≥50% hydrolysed to tropine and tropic acid |
| Onset of action | c. 1 minute |
| Elimination half-life | 2 hours |
| Duration of action | 30 to 60 min |
| Excretion | 15–50% excreted unchanged in urine |
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| ECHA InfoCard | 100.000.096 |
| Chemical and physical data | |
| Formula | C17H23NO3 |
| Molar mass | 289.375 g·mol−1 |
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Common side effects include dry mouth, abnormally large pupils, urinary retention, constipation, and a fast heart rate. It should generally not be used in people with closed-angle glaucoma. While there is no evidence that its use during pregnancy causes birth defects, this has not been well studied so sound clinical judgment should be used. It is likely safe during breastfeeding. It is an antimuscarinic (a type of anticholinergic) that works by inhibiting the parasympathetic nervous system.
Atropine occurs naturally in a number of plants of the nightshade family, including deadly nightshade (belladonna), Jimson weed, and mandrake. It was first isolated in 1833, It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication.