Ataxia telangiectasia and Rad3 related

ATR
Identifiers
Aliases	ATR, ATR serine/threonine kinase, FCTCS, FRP1, MEC1, SCKL, SCKL1
External IDs	OMIM: 601215 MGI: 108028 HomoloGene: 96916 GeneCards: ATR
Gene location (Human)
Chr.	Chromosome 3 (human)
End	142,578,733 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	95,833,834 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; caput epididymis; ; tibia; ; corpus epididymis; ; germinal epithelium; ; middle temporal gyrus; ; bronchial epithelial cell; ; visceral pleura; ; parietal pleura;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; pineal gland; ; ovary; ; cumulus cell; ; secondary oocyte; ; primitive streak; ; vas deferens; ; Paneth cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; DNA binding; protein kinase activity; nucleotide binding; kinase activity; MutSalpha complex binding; protein binding; MutLalpha complex binding; ATP binding; protein serine/threonine kinase activity;
Cellular component	PML body; Golgi apparatus; nucleoplasm; chromosome; nucleus;
Biological process	interstrand cross-link repair; phosphorylation; establishment of protein-containing complex localization to telomere; replicative senescence; cellular response to UV; DNA damage checkpoint signaling; positive regulation of telomerase catalytic core complex assembly; negative regulation of DNA replication; positive regulation of telomere maintenance via telomerase; protein localization to chromosome, telomeric region; multicellular organism development; DNA replication; peptidyl-serine phosphorylation; cellular response to gamma radiation; regulation of cellular response to heat; protein autophosphorylation; positive regulation of DNA damage response, signal transduction by p53 class mediator; DNA repair; establishment of RNA localization to telomere; cellular response to DNA damage stimulus; telomere maintenance; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	545
	245000
	ENSG00000175054
	ENSMUSG00000032409
	Q13535
	Q9JKK8
	NM_001184; NM_001354579
	NM_019864
	NP_001175; NP_001341508
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase ATR, also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1), is an enzyme that, in humans, is encoded by the ATR gene. It is a large kinase of about 301.66 kDa. ATR belongs to the phosphatidylinositol 3-kinase-related kinase protein family. ATR is activated in response to single strand breaks, and works with ATM to ensure genome integrity.

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