Apelin

APLN
Identifiers
Aliases	APLN, APEL, XNPEP2, apelin
External IDs	OMIM: 300297 MGI: 1353624 HomoloGene: 8498 GeneCards: APLN
Gene location (Human)
Chr.	X chromosome (human)
End	129,654,956 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	47,123,730 bp
RNA expression pattern
	Top expressed in
	substantia nigra; ; subthalamic nucleus; ; hypothalamus; ; amygdala; ; inferior ganglion of vagus nerve; ; external globus pallidus; ; ventral tegmental area; ; medulla oblongata; ; vein; ; pericardium;
	Top expressed in
	pericardium; ; right ventricle; ; right lung; ; left lung; ; entorhinal cortex; ; digastric muscle; ; left lung lobe; ; dermis; ; right lung lobe; ; sternocleidomastoid muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	signaling receptor binding; G protein-coupled receptor binding; hormone activity; apelin receptor binding; protein homodimerization activity;
Cellular component	perinuclear region of cytoplasm; extracellular space; extracellular region;
Biological process	positive regulation of corticotropin-releasing hormone secretion; negative regulation of vasoconstriction; regulation of the force of heart contraction; regulation of respiratory gaseous exchange; positive regulation of corticotropin secretion; regulation of body fluid levels; immune response; feeding behavior; positive regulation of cell population proliferation; positive regulation of heat generation; lactation; positive regulation of phosphorylation; signal transduction; signaling; apelin receptor signaling pathway; positive regulation of G protein-coupled receptor internalization; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; drinking behavior; negative regulation of blood pressure; positive regulation of heart contraction; coronary vasculature development; negative regulation of gene expression; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of vascular associated smooth muscle cell proliferation; positive regulation of vascular endothelial cell proliferation; angiogenesis; multicellular organism development; gastrulation;
	Sources:Amigo / QuickGO
Orthologs
	8862
	30878
	ENSG00000171388
	ENSMUSG00000037010
	Q9ULZ1
	Q9R0R4
	NM_017413
	NM_013912
	NP_059109
	NP_038940
	Wikidata
View/Edit Human	View/Edit Mouse

Apelin (also known as APLN) is a peptide that in humans is encoded by the APLN gene. Apelin is one of two endogenous ligands for the G-protein-coupled APJ receptor that is expressed at the surface of some cell types. It is widely expressed in various organs such as the heart, lung, kidney, liver, adipose tissue, gastrointestinal tract, brain, adrenal glands, endothelium, and human plasma.

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