Annexin
Annexin is a common name for a group of cellular proteins. They are mostly found in eukaryotic organisms (animal, plant and fungi).
| Annexin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Structure of human annexin III. | |||||||||
| Identifiers | |||||||||
| Symbol | Annexin | ||||||||
| Pfam | PF00191 | ||||||||
| InterPro | IPR001464 | ||||||||
| PROSITE | PDOC00195 | ||||||||
| SCOP2 | 2ran / SCOPe / SUPFAM | ||||||||
| TCDB | 1.A.31 | ||||||||
| OPM superfamily | 41 | ||||||||
| OPM protein | 1w3w | ||||||||
| |||||||||
In humans, the annexins are found inside the cell. However some annexins (Annexin A1, Annexin A2, and Annexin A5) can be secreted from the cytoplasm to outside cellular environments, such as blood.
Annexin is also known as lipocortin. Lipocortins suppress phospholipase A2. Increased expression of the gene coding for annexin-1 is one of the mechanisms by which glucocorticoids (such as cortisol) inhibit inflammation.
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