Anileridine

Anileridine
Clinical data
Trade names	Leritine
AHFS/Drugs.com	Monograph
Routes of; administration	Tablets, injection
ATC code	N01AH05 (WHO) ;
Legal status
Legal status	AU: S8 (Controlled drug); BR: Class A1 (Narcotic drugs); CA: Schedule I; DE: Anlage I (Authorized scientific use only); US: Schedule II;
Pharmacokinetic data
Protein binding	> 95%
Metabolism	Hepatic
Identifiers
	IUPAC name Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate;
CAS Number	144-14-9 ;
PubChem CID	8944;
IUPHAR/BPS	7115;
DrugBank	DB00913 ;
ChemSpider	8600 ;
UNII	71Q1A3O279;
KEGG	D02941 ;
ChEBI	CHEBI:61203 ;
ChEMBL	ChEMBL1201347 ;
CompTox Dashboard (EPA)	DTXSID8022610 ;
Chemical and physical data
Formula	C22H28N2O2
Molar mass	352.478 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	83 °C (181 °F)
	SMILES O=C(OCC)C3(c1ccccc1)CCN(CCc2ccc(N)cc2)CC3;
	InChI InChI=1S/C22H28N2O2/c1-2-26-21(25)22(19-6-4-3-5-7-19)13-16-24(17-14-22)15-12-18-8-10-20(23)11-9-18/h3-11H,2,12-17,23H2,1H3 ; Key:LKYQLAWMNBFNJT-UHFFFAOYSA-N ;
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Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s. It differs from pethidine (meperidine) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.

Anileridine is no longer manufactured in the US or Canada. Anileridine is in Schedule II of the Controlled Substances Act 1970 of the United States as ACSCN 9020 with a zero aggregate manufacturing quota as of 2014. The free base conversion ratio for salts includes 0.83 for the dihydrochloride and 0.73 for the phosphate. It is also under international control per UN treaties.

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