Angiofibroma
Angiofibroma (AGF) is a descriptive term for a wide range of benign skin or mucous membrane (i.e. the outer membrane lining body cavities such as the mouth and nose) lesions in which individuals have:
- benign papules, i.e. pinhead-sized elevations that lack visible evidence of containing fluid;
- nodules, i.e. small firm lumps usually >0.1 cm in diameter; and/or
- tumors, i.e. masses often regarded as ~0.8 cm or larger.
| Angiofibroma | |
|---|---|
| Angiofibroma, Hematoxylin and eosin stain, magnification ×10. | |
| Specialty | Oncology |
| Symptoms | Itchiness and sometimes bleeding. |
| Complications | Facial disfigurement and stigmatization. |
| Causes | Local overgrowth of collagen, fibroblasts, and blood vessels. |
| Risk factors | Tuberous sclerosis, Birt-Hogg-Dubé syndrome, and Multiple endocrine neoplasia type 1. |
| Diagnostic method | Skin biopsy. |
| Differential diagnosis | Intradermal melanocytic naevus, Acne, Basal cell carcinoma, Viral warts, Subungual exostosis, Molluscum contagiosum, and Anogenital warts. |
| Treatment | Excision, Dermabrasion, Using lasers, electrical, and radiofrequency devices, Cryotherapy, Topical podophyllotoxin, Topical rapamycin, and Topical beta-blockers. |
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