WDTC1
WDTC1 ("Adipose") is a gene associated with obesity.
| WD and tetratricopeptide repeats 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | WDTC1 | ||||||
| NCBI gene | 23038 | ||||||
| HGNC | 29175 | ||||||
| RefSeq | NM_015023 | ||||||
| UniProt | Q8N5D0 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p35.3 | ||||||
| |||||||
WDTC1 is a gene that codes for a protein acting as a suppressor in lipid accumulation. WDTC1 protein consists of seven WD40 domains, three transient receptor potential channel protein-protein interaction domains, DDB1 binding elements, and a prenylated C-terminus. Reduced expression or disruption of WDTC1 gene is associated with obesity, increased triglyceride accumulation, and adipogenesis. WDTC1 is a factor in a complex composed of DDB1, CUL4, and ROC1 that restricts transcription in adipogenesis.
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