Adiponectin

ADIPOQ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DOU
Identifiers
Aliases	ADIPOQ, ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin, C1Q and collagen domain containing, Adiponectin
External IDs	OMIM: 605441 MGI: 106675 HomoloGene: 3525 GeneCards: ADIPOQ
Gene location (Human)
Chr.	Chromosome 3 (human)
End	186,858,463 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	22,976,778 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; pericardium; ; adipose tissue; ; subcutaneous adipose tissue; ; abdominal fat; ; parotid gland; ; lactiferous duct; ; vena cava; ; superficial temporal artery; ; synovial membrane;
	Top expressed in
	white adipose tissue; ; brown adipose tissue; ; subcutaneous adipose tissue; ; intercostal muscle; ; ankle joint; ; parotid gland; ; ankle; ; digastric muscle; ; cervix; ; vastus lateralis muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hormone activity; signaling receptor binding; cytokine activity; sialic acid binding; protein homodimerization activity; protein binding; identical protein binding; extracellular matrix structural constituent;
Cellular component	cell surface; endoplasmic reticulum; collagen; extracellular space; extracellular region; protein-containing complex; collagen-containing extracellular matrix;
Biological process	positive regulation of glucose import; positive regulation of protein phosphorylation; negative regulation of receptor binding; low-density lipoprotein particle clearance; negative regulation of blood pressure; negative regulation of macrophage differentiation; negative regulation of synaptic transmission; generation of precursor metabolites and energy; cellular response to epinephrine stimulus; negative regulation of gluconeogenesis; regulation of glucose metabolic process; circadian rhythm; fatty acid oxidation; positive regulation of interleukin-8 production; glucose metabolic process; protein heterotrimerization; negative regulation of heterotypic cell-cell adhesion; response to ethanol; negative regulation of inflammatory response; cellular response to cAMP; positive regulation of protein kinase A signaling; negative regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of signal transduction; positive regulation of protein metabolic process; negative regulation of fat cell differentiation; response to linoleic acid; detection of oxidative stress; glucose homeostasis; adiponectin-activated signaling pathway; response to tumor necrosis factor; positive regulation of blood pressure; response to nutrient levels; positive regulation of cholesterol efflux; negative regulation of MAP kinase activity; cellular response to insulin stimulus; positive regulation of peptidyl-tyrosine phosphorylation; fatty acid beta-oxidation; negative regulation of tumor necrosis factor production; protein localization to plasma membrane; negative regulation of hormone secretion; protein homooligomerization; response to sucrose; positive regulation of metanephric glomerular visceral epithelial cell development; positive regulation of renal albumin absorption; negative regulation of granulocyte differentiation; response to nutrient; negative regulation of protein autophosphorylation; negative regulation of intracellular protein transport; membrane depolarization; response to glucose; positive regulation of myeloid cell apoptotic process; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of metanephric mesenchymal cell migration; negative regulation of cell migration; positive regulation of fatty acid metabolic process; brown fat cell differentiation; positive regulation of cAMP-dependent protein kinase activity; positive regulation of glycogen (starch) synthase activity; negative regulation of transcription, DNA-templated; negative regulation of DNA biosynthetic process; positive regulation of protein kinase activity; response to hypoxia; negative regulation of phagocytosis; membrane hyperpolarization; negative regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of monocyte chemotactic protein-1 production; response to glucocorticoid; response to activity; negative regulation of platelet-derived growth factor receptor-alpha signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of ERK1 and ERK2 cascade; negative regulation of macrophage derived foam cell differentiation; regulation of fatty acid biosynthetic process; regulation of signaling receptor activity; negative regulation of vascular associated smooth muscle cell proliferation; negative regulation of vascular associated smooth muscle cell migration; response to bacterium; positive regulation of cold-induced thermogenesis; negative regulation of cold-induced thermogenesis; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	9370
	11450
	ENSG00000181092
	ENSMUSG00000022878
	Q15848
	Q60994
	NM_001177800; NM_004797
	NM_009605
	NP_001171271; NP_004788
	NP_033735
	Wikidata
View/Edit Human	View/Edit Mouse

Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein hormone and adipokine, which is involved in regulating glucose levels and fatty acid breakdown. In humans, it is encoded by the ADIPOQ gene and is produced primarily in adipose tissue, but also in muscle and even in the brain.

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