ATF1

ATF1
Identifiers
Aliases	ATF1, EWS-FUS/ATF-1, TREB36, activating transcription factor 1
External IDs	OMIM: 123803 MGI: 3037720 HomoloGene: 3790 GeneCards: ATF1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	50,821,162 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	52,886,387 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; parietal pleura; ; amniotic fluid; ; biceps brachii; ; visceral pleura; ; spongy bone; ; palpebral conjunctiva; ; Achilles tendon; ; tibia; ; vastus lateralis muscle;
	Top expressed in
	lens; ; testicle; ; liver; ; embryo; ; heart; ; cerebellum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein-containing complex binding;
Cellular component	ATF1-ATF4 transcription factor complex; transcription regulator complex; nucleoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; response to organic cyclic compound; transcription, DNA-templated; positive regulation of DNA replication; positive regulation of neuron projection development; response to cobalt ion; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	466
	100040260
	ENSG00000123268
	ENSMUSG00000080968
	P18846
	n/a
	NM_005171
	XM_036162179
	NP_005162
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.