Acamprosate

Acamprosate, sold under the brand name Campral, is a medication used along with counseling to treat alcohol use disorder.

Acamprosate
Clinical data
Pronunciation/əˈkæmproʊseɪt/
Trade namesCampral EC
Other namesN-Acetyl homotaurine, Acamprosate calcium (JAN JP), Acamprosate calcium (USAN US)
Pregnancy
category
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailability11%
Protein bindingNegligible
MetabolismNil
Elimination half-life20 h to 33 h
ExcretionKidney
Identifiers
  • 3-Acetamidopropane-1-sulfonic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.071.495
Chemical and physical data
FormulaC5H11NO4S
Molar mass181.21 g·mol−1
3D model (JSmol)
  • [Ca+2].O=C(NCCCS(=O)(=O)[O-])C.[O-]S(=O)(=O)CCCNC(=O)C
  • InChI=1S/2C5H11NO4S.Ca/c2*1-5(7)6-3-2-4-11(8,9)10;/h2*2-4H2,1H3,(H,6,7)(H,8,9,10);/q;;+2/p-2 Y
  • Key:BUVGWDNTAWHSKI-UHFFFAOYSA-L Y
 NY (what is this?)  (verify)

Acamprosate is thought to stabilize chemical signaling in the brain that would otherwise be disrupted by alcohol withdrawal. When used alone, acamprosate is not an effective therapy for alcohol use disorder in most individuals; studies have found that acamprosate works best when used in combination with psychosocial support since the drug facilitates a reduction in alcohol consumption as well as full abstinence.

Serious side effects include allergic reactions, abnormal heart rhythms, and low or high blood pressure, while less serious side effects include headaches, insomnia, and impotence. Diarrhea is the most common side-effect. It is unclear if use is safe during pregnancy.

It is on the World Health Organization's List of Essential Medicines.

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