ATF4

ATF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CI6
Identifiers
Aliases	ATF4, CREB-2, CREB2, TAXREB67, TXREB, activating transcription factor 4
External IDs	OMIM: 604064 MGI: 88096 HomoloGene: 1266 GeneCards: ATF4
Gene location (Human)
Chr.	Chromosome 22 (human)
End	39,522,683 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	80,141,742 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; body of stomach; ; subcutaneous adipose tissue; ; fundus; ; right coronary artery; ; body of pancreas; ; left coronary artery; ; prostate; ; ascending aorta; ; gastric mucosa;
	Top expressed in
	ankle joint; ; calvaria; ; lacrimal gland; ; plantaris muscle; ; temporal muscle; ; islet of Langerhans; ; triceps brachii muscle; ; parotid gland; ; extensor digitorum longus muscle; ; superior surface of tongue;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; core promoter sequence-specific DNA binding; protein C-terminus binding; protein binding; leucine zipper domain binding; protein heterodimerization activity; protein kinase binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; ATF1-ATF4 transcription factor complex; ATF4-CREB1 transcription factor complex; transcription regulator complex; dendrite membrane; nucleus; Lewy body core; nuclear periphery; membrane; plasma membrane; nucleoplasm; microtubule organizing center; neuron projection; cytoskeleton; CHOP-ATF4 complex; centrosome; protein-containing complex; RNA polymerase II transcription regulator complex;
Biological process	gamma-aminobutyric acid signaling pathway; gluconeogenesis; regulation of transcription, DNA-templated; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; regulation of transcription by RNA polymerase II; negative regulation of oxidative stress-induced neuron death; cellular response to amino acid starvation; mRNA transcription by RNA polymerase II; circadian regulation of gene expression; response to endoplasmic reticulum stress; PERK-mediated unfolded protein response; response to manganese-induced endoplasmic reticulum stress; positive regulation of transcription, DNA-templated; positive regulation of neuron apoptotic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of gene expression; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; circadian rhythm; negative regulation of potassium ion transport; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance; cellular response to glucose starvation; negative regulation of translational initiation in response to stress; rhythmic process; cellular response to UV; positive regulation of transcription from RNA polymerase II promoter in response to stress; cellular amino acid metabolic process; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of apoptotic process; positive regulation of vascular endothelial growth factor production; positive regulation of transcription by RNA polymerase I; cellular response to dopamine; response to toxic substance; neuron differentiation; cellular response to oxygen-glucose deprivation; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; cellular calcium ion homeostasis; positive regulation of biomineral tissue development; negative regulation of cold-induced thermogenesis; positive regulation of vascular associated smooth muscle cell apoptotic process; positive regulation of sodium-dependent phosphate transport;
	Sources:Amigo / QuickGO
Orthologs
	468
	11911
	ENSG00000128272
	ENSMUSG00000042406
	P18848
	Q06507
	NM_182810; NM_001675
	NM_001287180; NM_009716
	NP_001666; NP_877962
	NP_001274109; NP_033846
	Wikidata
View/Edit Human	View/Edit Mouse

Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a protein that in humans is encoded by the ATF4 gene.

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