Serine/arginine-rich splicing factor 1

SRSF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X4A, 2M7S, 2M8D, 2O3D, 3BEG, 4C0O
Identifiers
Aliases	SRSF1, ASF, SF2, SF2p33, SFRS1, SRp30a, ASF/SF2, serine/arginine-rich splicing factor 1, serine and arginine rich splicing factor 1
External IDs	OMIM: 600812 MGI: 98283 HomoloGene: 31411 GeneCards: SRSF1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	58,007,346 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	87,944,581 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; rectum; ; Achilles tendon; ; canal of the cervix; ; right uterine tube; ; monocyte; ; left uterine tube; ; anterior pituitary; ; left lobe of thyroid gland; ; right lobe of thyroid gland;
	Top expressed in
	spermatocyte; ; yolk sac; ; superior frontal gyrus; ; lip; ; esophagus; ; morula; ; spermatid; ; neural tube; ; lens; ; cerebellar cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	RS domain binding; protein binding; RNA binding; nucleic acid binding; mRNA binding; protein kinase B binding; DNA topoisomerase binding;
Cellular component	cytoplasm; nuclear speck; catalytic step 2 spliceosome; exon-exon junction complex; nucleoplasm; spliceosomal complex; extracellular exosome; nucleus;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA transport; cardiac muscle contraction; mRNA processing; in utero embryonic development; mRNA export from nucleus; mRNA splice site selection; mRNA 5'-splice site recognition; mRNA 3'-end processing; liver regeneration; alternative mRNA splicing, via spliceosome; RNA splicing; oligodendrocyte differentiation; RNA export from nucleus; positive regulation of RNA splicing; transport; regulation of alternative mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	6426
	110809
	ENSG00000136450
	ENSMUSG00000018379
	Q07955
	Q6PDM2
	NM_001078166; NM_006924
	NM_001078167; NM_173374
	NP_001071634; NP_008855
	NP_001071635; NP_775550
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a protein that in humans is encoded by the SRSF1 gene. ASF/SF2 is an essential sequence specific splicing factor involved in pre-mRNA splicing. SRSF1 is the gene that codes for ASF/SF2 and is found on chromosome 17. The resulting splicing factor is a protein of approximately 33 kDa. ASF/SF2 is necessary for all splicing reactions to occur, and influences splice site selection in a concentration-dependent manner, resulting in alternative splicing. In addition to being involved in the splicing process, ASF/SF2 also mediates post-splicing activities, such as mRNA nuclear export and translation.

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