APRIL (protein)

TNFSF13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZCH
Identifiers
Aliases	TNFSF13, APRIL, CD256, TALL-2, TALL2, TRDL-1, ZTNF2, UNQ383/PRO715, TNLG7B, tumor necrosis factor superfamily member 13, TNF superfamily member 13
External IDs	OMIM: 604472 MGI: 1916833 HomoloGene: 56971 GeneCards: TNFSF13
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,561,608 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,576,610 bp
RNA expression pattern
	Top expressed in
	monocyte; ; duodenum; ; gallbladder; ; blood; ; right lung; ; upper lobe of left lung; ; kidney; ; rectum; ; salivary gland; ; caudate nucleus;
	Top expressed in
	colon; ; ileum; ; jejunum; ; duodenum; ; lung; ; esophagus; ; bone marrow; ; ovary; ; white adipose tissue; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	signaling receptor binding; tumor necrosis factor receptor binding; cytokine activity;
Cellular component	cytosol; membrane; nucleoplasm; cytoplasm; extracellular exosome; extracellular region; extracellular space;
Biological process	tumor necrosis factor-mediated signaling pathway; regulation of mRNA stability; positive regulation of cell population proliferation; immune system process; signal transduction; positive regulation of isotype switching to IgA isotypes; immune response; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	8741
	69583
	ENSG00000161955
	ENSMUSG00000089669
	O75888
	Q9D777
NM_001198622; NM_001198623; NM_001198624; NM_003808; NM_172087;
	NM_172088
	NM_001159505; NM_023517
NP_001185551; NP_001185552; NP_001185553; NP_003799; NP_742084;
	NP_742085
	NP_001152977; NP_076006
	Wikidata
View/Edit Human	View/Edit Mouse

A proliferation-inducing ligand (APRIL), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI. It is encoded by the TNFSF13 gene.

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