APAF1

APAF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C15, 1CWW, 1CY5, 1Z6T, 2P1H, 2YGS, 3J2T, 3YGS, 4RHW, 3JBT
Identifiers
Aliases	APAF1, APAF-1, CED4, apoptotic peptidase activating factor 1
External IDs	OMIM: 602233 MGI: 1306796 HomoloGene: 7626 GeneCards: APAF1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	98,735,433 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	91,082,770 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; bone marrow cells; ; ganglionic eminence; ; Achilles tendon; ; spongy bone; ; tibia; ; Brodmann area 9; ; germinal epithelium; ; amygdala;
	Top expressed in
	dermis; ; ureter; ; jejunum; ; vas deferens; ; ileum; ; cumulus cell; ; abdominal wall; ; saccule; ; duodenum; ; intestinal epithelium;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	heat shock protein binding; ADP binding; protein binding; identical protein binding; ATP binding; nucleotide binding; cysteine-type endopeptidase activator activity involved in apoptotic process;
Cellular component	cytoplasm; cytosol; extracellular exosome; nucleus; apoptosome; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen; protein-containing complex;
Biological process	cellular response to transforming growth factor beta stimulus; neuron apoptotic process; regulation of apoptotic process; cell differentiation; response to hypoxia; response to nutrient; response to G1 DNA damage checkpoint signaling; human ageing; positive regulation of apoptotic signaling pathway; glial cell apoptotic process; nervous system development; multicellular organism development; cardiac muscle cell apoptotic process; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; neural tube closure; brain development; positive regulation of apoptotic process; apoptotic signaling pathway; forebrain development; regulation of apoptotic DNA fragmentation; protein homooligomerization; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; apoptotic process; neutrophil degranulation; negative regulation of G0 to G1 transition; kidney development;
	Sources:Amigo / QuickGO
Orthologs
	317
	11783
	ENSG00000120868
	ENSMUSG00000019979
	O14727
	O88879
	NM_001160; NM_013229; NM_181861; NM_181868; NM_181869
	NM_001042558; NM_001282947; NM_009684
	NP_001151; NP_037361; NP_863651; NP_863658; NP_863659
	NP_001036023; NP_001269876; NP_033814
	Wikidata
View/Edit Human	View/Edit Mouse

Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene.

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