JWH-018

JWH-018
Clinical data
Trade names	Spice, K2
Routes of; administration	Smoked, Oral
Legal status
Legal status	AU: S9 (Prohibited substance); BR: Class F2 (Prohibited psychotropics); CA: Schedule II, In general uncontrolled could be illegal to sell for human consumption or the analogue acts in several countries.; DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B; US: Schedule I; UN: Psychotropic Schedule II;
Identifiers
	IUPAC name (Naphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone;
CAS Number	209414-07-3 ;
PubChem CID	10382701;
ChemSpider	8558143 ;
UNII	G391998J57;
KEGG	C22748 ;
ChEMBL	ChEMBL561013 ;
CompTox Dashboard (EPA)	DTXSID10175117 ;
ECHA InfoCard	100.163.574
Chemical and physical data
Formula	C24H23NO
Molar mass	341.454 g·mol−1
3D model (JSmol)	Interactive image;
Solubility in water	hydrophobic, n/a mg/mL (20 °C)
	SMILES CCCCCN1C=C(C(C2=CC=CC3=CC=CC=C32)=O)C4=CC=CC=C41;
	InChI InChI=1S/C24H23NO/c1-2-3-8-16-25-17-22(20-13-6-7-15-23(20)25)24(26)21-14-9-11-18-10-4-5-12-19(18)21/h4-7,9-15,17H,2-3,8,16H2,1H3 ; Key:JDNLPKCAXICMBW-UHFFFAOYSA-N ;
	(what is this?) (verify)

JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO or AM-678) is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with some selectivity for CB₂. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as "incense blends".

As a full agonist at both the CB₁ and CB₂ cannabinoid receptors, this chemical compound is classified as an analgesic medication. The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis.

These compounds work by mimicking the body's naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling. As the cause is poorly understood in chronic pain states, more research and development must be done before the therapeutic potential of this class of biologic compounds can be realized.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.