ADAM12

ADAM12
Identifiers
Aliases	ADAM12, ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA, ADAM metallopeptidase domain 12
External IDs	OMIM: 602714 MGI: 105378 HomoloGene: 74862 GeneCards: ADAM12
Gene location (Human)
Chr.	Chromosome 10 (human)
End	126,388,477 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	133,833,875 bp
RNA expression pattern
	Top expressed in
	placenta; ; stromal cell of endometrium; ; tibia; ; gallbladder; ; lactiferous duct; ; smooth muscle tissue; ; periodontal fiber; ; adipose tissue; ; islet of Langerhans; ; amniotic fluid;
	Top expressed in
	calvaria; ; body of femur; ; belly cord; ; human mandible; ; lesser wing of sphenoid bone; ; uterus; ; dermis; ; left lung lobe; ; internal carotid artery; ; fossa;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; peptidase activity; metalloendopeptidase activity; protein binding; hydrolase activity; metal ion binding; metallopeptidase activity;
Cellular component	integral component of membrane; extracellular region; membrane; nucleoplasm; plasma membrane;
Biological process	cell adhesion; myoblast fusion; proteolysis; extracellular matrix organization; positive regulation of angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	8038
	11489
	ENSG00000148848
	ENSMUSG00000054555
	O43184
	Q61824
	NM_021641; NM_001288973; NM_001288974; NM_001288975; NM_003474
	NM_007400
	NP_001275902; NP_001275903; NP_001275904; NP_003465; NP_067673
	NP_031426
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 12 (previously Meltrin) is an enzyme that in humans is encoded by the ADAM12 gene. ADAM12 has two splice variants: ADAM12-L, the long form, has a transmembrane region and ADAM12-S, a shorter variant, is soluble and lacks the transmembrane and cytoplasmic domains.

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