Actin, cytoplasmic 2

ACTG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5JLH
Identifiers
Aliases	ACTG1, ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176, actin gamma 1
External IDs	OMIM: 102560 MGI: 87906 HomoloGene: 74402 GeneCards: ACTG1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,523,847 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,239,368 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; embryo; ; ganglionic eminence; ; parietal pleura; ; visceral pleura; ; spinal ganglia; ; pericardium; ; mucosa of urinary bladder; ; lower lobe of lung; ; trigeminal ganglion;
	Top expressed in
	ganglionic eminence; ; neural tube; ; mesencephalon; ; placenta; ; stomach; ; superior frontal gyrus; ; hippocampus proper; ; intestine; ; colon; ; islet of Langerhans;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; ATP binding; ubiquitin protein ligase binding; identical protein binding; structural constituent of cytoskeleton; profilin binding;
Cellular component	focal adhesion; nucleus; dense body; cytoplasm; membrane; cytosol; extracellular exosome; blood microparticle; plasma membrane; cytoskeleton; extracellular matrix; extracellular space; actin cytoskeleton; myofibril; filamentous actin; myelin sheath; actin filament;
Biological process	cell junction assembly; ephrin receptor signaling pathway; platelet aggregation; Fc-gamma receptor signaling pathway involved in phagocytosis; retina homeostasis; vascular endothelial growth factor receptor signaling pathway; membrane organization; sarcomere organization;
	Sources:Amigo / QuickGO
Orthologs
	71
	11465
	ENSG00000184009
	ENSMUSG00000062825
	P63261
	P63260
	NM_001199954; NM_001614
	NM_009609; NM_001313923
	NP_001186883; NP_001605
	NP_001300852; NP_033739
	Wikidata
View/Edit Human	View/Edit Mouse

Actin, cytoplasmic 2, or gamma-actin is a protein that in humans is encoded by the ACTG1 gene. Gamma-actin is widely expressed in cellular cytoskeletons of many tissues; in adult striated muscle cells, gamma-actin is localized to Z-discs and costamere structures, which are responsible for force transduction and transmission in muscle cells. Mutations in ACTG1 have been associated with nonsyndromic hearing loss and Baraitser-Winter syndrome, as well as susceptibility of adolescent patients to vincristine toxicity.

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