Beta-actin

ACTB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BYH, 3D2U, 3J82, 3LUE
Identifiers
Aliases	ACTB, BRWS1, PS1TP5BP1, Beta-actin, actin, beta, actin beta
External IDs	OMIM: 102630 MGI: 87904 HomoloGene: 110648 GeneCards: ACTB
Gene location (Human)
Chr.	Chromosome 7 (human)
End	5,563,902 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	142,892,509 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; urethra; ; postcentral gyrus; ; synovial joint; ; orbitofrontal cortex; ; Brodmann area 46; ; nipple; ; vena cava; ; olfactory bulb; ; Region I of hippocampus proper;
	Top expressed in
	vas deferens; ; maxillary prominence; ; ventromedial nucleus; ; abdominal wall; ; medial ganglionic eminence; ; left lung lobe; ; hand; ; dermis; ; somite; ; foot;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; nucleotide binding; nitric-oxide synthase binding; Tat protein binding; structural constituent of cytoskeleton; protein binding; kinesin binding; identical protein binding; nucleosomal DNA binding; ATP binding;
Cellular component	cytoplasm; blood microparticle; membrane; focal adhesion; NuA4 histone acetyltransferase complex; plasma membrane; nucleoplasm; cytoplasmic ribonucleoprotein granule; extracellular exosome; cytoskeleton; dense body; cortical cytoskeleton; cytosol; myelin sheath; extracellular space;
Biological process	epigenetic maintenance of chromatin in transcription-competent conformation; substantia nigra development; Fc-gamma receptor signaling pathway involved in phagocytosis; ephrin receptor signaling pathway; retina homeostasis; vascular endothelial growth factor receptor signaling pathway; platelet aggregation; cell junction assembly; cytoskeleton organization; protein deubiquitination; membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	60
	11461
	ENSG00000075624
	ENSMUSG00000029580
	P60709
	P60710
	NM_001101
	NM_007393
	NP_001092
	NP_031419
	Wikidata
View/Edit Human	View/Edit Mouse

Actin beta (HUGO Gene Nomenclature Committee abbreviation ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.

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