ABCG2

ABCG2
Identifiers
Aliases	ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, MXR-1, ATP binding cassette subfamily G member 2 (Junior blood group)
External IDs	OMIM: 603756 MGI: 1347061 HomoloGene: 55852 GeneCards: ABCG2
Gene location (Human)
Chr.	Chromosome 4 (human)
End	88,231,628 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	58,672,661 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; endothelial cell; ; seminal vesicula; ; duodenum; ; substantia nigra; ; internal globus pallidus; ; placenta; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; postcentral gyrus;
	Top expressed in
	proximal tubule; ; kidney; ; ileum; ; yolk sac; ; jejunum; ; sciatic nerve; ; intestinal epithelium; ; primitive streak; ; intestinal villus; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ABC-type xenobiotic transporter activity; heme transmembrane transporter activity; protein homodimerization activity; transporter activity; ATPase activity; protein binding; ATP binding; ATPase-coupled transmembrane transporter activity; cholesterol transfer activity; identical protein binding; xenobiotic transmembrane transporter activity;
Cellular component	mitochondrial membranes; membrane; mitochondrion; nucleus; plasma membrane; integral component of membrane; apical plasma membrane; receptor complex;
Biological process	urate metabolic process; cellular iron ion homeostasis; heme transport; xenobiotic transmembrane transport; xenobiotic transport; transmembrane transport; cholesterol efflux; cellular detoxification;
	Sources:Amigo / QuickGO
Orthologs
	9429
	26357
	ENSG00000118777
	ENSMUSG00000029802
	Q9UNQ0
	Q7TMS5
NM_001257386; NM_004827; NM_001348985; NM_001348986; NM_001348987;
	NM_001348988; NM_001348989
	NM_011920; NM_001355477; NM_001381925; NM_001381926; NM_001381927
NP_001244315; NP_004818; NP_001335914; NP_001335915; NP_001335916;
	NP_001335917; NP_001335918
	NP_036050; NP_001342406; NP_001368854; NP_001368855; NP_001368856
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338 (cluster of differentiation w338). ABCG2 is a translocation protein used to actively pump drugs and other compounds against their concentration gradient using the bonding and hydrolysis of ATP as the energy source.

ABCG2 forms into a homodimer to assume its active transport conformation. The dimer weighs approximately 144 kDa. The expression of this transport protein is highly conserved throughout the animal kingdom, pointing to its importance.

Substrate binding with compounds occurs in the large central cavity. ABCG2 can bind to a broad range of compounds but binds strongest to flat, polycyclic chemicals with lots of hydrophobic character.

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