5-HT₇ receptor

HTR7
Identifiers
Aliases	HTR7, 5-HT7, 5-HT7 receptor, 5-hydroxytryptamine receptor 7
External IDs	OMIM: 182137 MGI: 99841 HomoloGene: 20244 GeneCards: HTR7
Gene location (Human)
Chr.	Chromosome 10 (human)
End	90,858,039 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	36,034,907 bp
RNA expression pattern
	Top expressed in
	sperm; ; secondary oocyte; ; testicle; ; gastric mucosa; ; stromal cell of endometrium; ; skeletal muscle tissue; ; amniotic fluid; ; right coronary artery; ; prefrontal cortex; ; monocyte;
	Top expressed in
	medial dorsal nucleus; ; ventromedial nucleus; ; medial geniculate nucleus; ; mammillary body; ; paraventricular nucleus of hypothalamus; ; utricle; ; lateral geniculate nucleus; ; dorsomedial hypothalamic nucleus; ; lateral hypothalamus; ; globus pallidus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; neurotransmitter receptor activity; G protein-coupled serotonin receptor activity; serotonin binding; protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; dendrite;
Biological process	smooth muscle contraction; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; circadian rhythm; blood circulation; vasoconstriction; signal transduction; chemical synaptic transmission; adenylate cyclase-inhibiting serotonin receptor signaling pathway; G protein-coupled receptor signaling pathway; G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3363
	15566
	ENSG00000148680
	ENSMUSG00000024798
	P34969
	P32304
	NM_019860; NM_000872; NM_019859
NM_008315; NM_001347442; NM_001360297; NM_001360298; NM_001360300;
	NM_001360318
	NP_000863; NP_062873; NP_062874
NP_001334371; NP_032341; NP_001347226; NP_001347227; NP_001347229;
	NP_001347247
	Wikidata
View/Edit Human	View/Edit Mouse

The 5-HT₇ receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) The 5-HT₇ receptor is coupled to G_s (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels. This receptor has been a drug development target for the treatment of several clinical disorders. The 5-HT₇ receptor is encoded by the HTR7 gene, which in humans is transcribed into 3 different splice variants.

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5-HT7 receptor

5-HT₇ receptor