5-HT₆ receptor

HTR6
Identifiers
Aliases	HTR6, 5-HT6, 5-HT6R, 5-HT6 receptor, 5-hydroxytryptamine receptor 6
External IDs	OMIM: 601109 MGI: 1196627 HomoloGene: 673 GeneCards: HTR6
Gene location (Human)
Chr.	Chromosome 1 (human)
End	19,680,966 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,802,881 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; pancreatic ductal cell; ; frontal pole; ; mucosa of urinary bladder; ; middle frontal gyrus; ; external globus pallidus; ; body of tongue; ; pericardium; ; inferior ganglion of vagus nerve; ; Brodmann area 46;
	Top expressed in
	superior frontal gyrus; ; cerebellar cortex; ; hippocampus proper; ; neck; ; digastric muscle; ; olfactory bulb; ; thoracic diaphragm; ; carotid body; ; submandibular gland; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histamine receptor activity; protein binding; G protein-coupled receptor activity; signal transducer activity; neurotransmitter receptor activity; G protein-coupled serotonin receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; cilium; membrane; dendrite;
Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; cerebral cortex cell migration; positive regulation of TOR signaling; signal transduction; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3362
	15565
	ENSG00000158748
	ENSMUSG00000028747
	P50406
	Q9R1C8
	NM_000871
	NM_021358; NM_001377096
	NP_000862
	NP_067333; NP_001364025
	Wikidata
View/Edit Human	View/Edit Mouse

The 5HT₆ receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT). It is a G protein-coupled receptor (GPCR) that is coupled to G_s and mediates excitatory neurotransmission. HTR6 denotes the human gene encoding for the receptor.

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5-HT6 receptor

5-HT₆ receptor