5-HT_2C receptor

HTR2C
Identifiers
Aliases	HTR2C, 5-HT2C, 5-5HTR1C, 5-HT1C, 5-HT2C receptor, 5-hydroxytryptamine receptor 2C
External IDs	OMIM: 312861 MGI: 96281 HomoloGene: 20242 GeneCards: HTR2C
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	145,980,273 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; superior vestibular nucleus; ; nucleus accumbens; ; caudate nucleus; ; middle frontal gyrus; ; hypothalamus; ; putamen; ; Region I of hippocampus proper; ; endothelial cell; ; entorhinal cortex;
	Top expressed in
	medial dorsal nucleus; ; nucleus accumbens; ; lateral hypothalamus; ; dorsal tegmental nucleus; ; dorsomedial hypothalamic nucleus; ; medial vestibular nucleus; ; olfactory tubercle; ; ventral tegmental area; ; subiculum; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; G protein-coupled receptor activity; signal transducer activity; G protein-coupled serotonin receptor activity; Gq/11-coupled serotonin receptor activity; serotonin binding; neurotransmitter receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; dendrite;
Biological process	release of sequestered calcium ion into cytosol; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; phospholipase C-activating serotonin receptor signaling pathway; locomotory behavior; positive regulation of phosphatidylinositol biosynthetic process; cellular calcium ion homeostasis; behavioral fear response; regulation of nervous system process; cGMP biosynthetic process; phospholipase C-activating G protein-coupled receptor signaling pathway; serotonin receptor signaling pathway; feeding behavior; positive regulation of ERK1 and ERK2 cascade; regulation of corticotropin-releasing hormone secretion; regulation of appetite; positive regulation of fat cell differentiation; signal transduction; chemical synaptic transmission; G protein-coupled receptor signaling pathway; animal behaviour; cGMP-mediated signaling; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
	Sources:Amigo / QuickGO
Orthologs
	3358
	15560
	n/a
	ENSMUSG00000041380
	P28335
	P34968
	NM_001256761; NM_000868; NM_001256760
	NM_008312
	NP_000859; NP_001243689; NP_001243690
	NP_032338
	Wikidata
View/Edit Human	View/Edit Mouse

The 5-HT_2C receptor is a subtype of the 5-HT2 receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Like all 5-HT2 receptors, it is a G protein-coupled receptor (GPCR) that is coupled to G_q/G₁₁ and mediates excitatory neurotransmission. HTR2C denotes the human gene encoding for the receptor, that in humans is located on the X chromosome. As males have one copy of the gene and females have one of the two copies of the gene repressed, polymorphisms at this receptor can affect the two sexes to differing extent.

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5-HT2C receptor

5-HT_2C receptor