5-HT_2B receptor

HTR2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NC3, 4IB4
Identifiers
Aliases	HTR2B, 5-HT(2B), 5-HT2B, 5-HT-2B, 5-hydroxytryptamine receptor 2B
External IDs	OMIM: 601122 MGI: 109323 HomoloGene: 55492 GeneCards: HTR2B
Gene location (Human)
Chr.	Chromosome 2 (human)
End	231,125,042 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	86,039,692 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; caput epididymis; ; corpus epididymis; ; left adrenal gland; ; smooth muscle tissue; ; myometrium; ; right coronary artery; ; canal of the cervix; ; thoracic aorta; ; ascending aorta;
	Top expressed in
	morula; ; calvaria; ; right lung lobe; ; uterus; ; lip; ; meninges; ; cumulus cell; ; esophagus; ; stomach; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; GTPase activator activity; signal transducer activity; G protein-coupled serotonin receptor activity; G-protein alpha-subunit binding; serotonin binding; neurotransmitter receptor activity;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; synapse; cell junction; neuron projection; integral component of plasma membrane; nucleoplasm; dendrite;
Biological process	intestine smooth muscle contraction; smooth muscle contraction; G protein-coupled receptor internalization; release of sequestered calcium ion into cytosol; regulation of behavior; positive regulation of endothelial cell proliferation; positive regulation of MAP kinase activity; phosphorylation; positive regulation of cytokine production; vasoconstriction; ERK1 and ERK2 cascade; positive regulation of phosphatidylinositol biosynthetic process; cardiac muscle hypertrophy; heart morphogenesis; cellular calcium ion homeostasis; neural crest cell differentiation; negative regulation of apoptotic process; negative regulation of cell death; activation of phospholipase C activity; protein kinase C signaling; cGMP biosynthetic process; cellular response to temperature stimulus; positive regulation of GTPase activity; heart development; positive regulation of nitric-oxide synthase activity; protein kinase C-activating G protein-coupled receptor signaling pathway; embryonic morphogenesis; serotonin receptor signaling pathway; neural crest cell migration; positive regulation of cell population proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of I-kappaB kinase/NF-kappaB signaling; phosphatidylinositol 3-kinase signaling; negative regulation of autophagy; positive regulation of cell division; calcium-mediated signaling; signal transduction; phospholipase C-activating G protein-coupled receptor signaling pathway; G protein-coupled serotonin receptor signaling pathway; G protein-coupled receptor signaling pathway; animal behaviour; cGMP-mediated signaling; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	3357
	15559
	ENSG00000135914
	ENSMUSG00000026228
	P41595
	Q02152
	NM_000867; NM_001320758
	NM_008311
	NP_000858; NP_001307687
	NP_032337
	Wikidata
View/Edit Human	View/Edit Mouse

5-Hydroxytryptamine receptor 2B (5-HT_2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene. 5-HT_2B is a member of the 5-HT₂ receptor family that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Like all 5-HT₂ receptors, the 5-HT_2B receptor is G_q/G₁₁-protein coupled, leading to downstream activation of phospholipase C.

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5-HT2B receptor

5-HT_2B receptor