3-dehydroquinate synthase
The enzyme 3-dehydroquinate synthase (EC 4.2.3.4) catalyzes the chemical reaction
- [[3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate]] 3-dehydroquinate + phosphate
| 3-dehydroquinate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Ribbon representation of the Helicobacter pylori 3-dehydroquinate synthase. | |||||||||
| Identifiers | |||||||||
| EC no. | 4.2.3.4 | ||||||||
| CAS no. | 37211-77-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| 3-dehydroquinate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
3-Dehydroquinate synthase homodimer, Aspergillus nidulans | |||||||||
| Identifiers | |||||||||
| Symbol | DHQ_synthase | ||||||||
| Pfam | PF01761 | ||||||||
| InterPro | IPR002658 | ||||||||
| SCOP2 | 1dqs / SCOPe / SUPFAM | ||||||||
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The protein uses NAD+ to catalyze the reaction. This reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids.
3-Dehydroquinate synthase belongs to the family of lyases, to be specific those carbon-oxygen lyases acting on phosphates. This enzyme participates in phenylalanine, tyrosine, and tryptophan biosynthesis. It employs one cofactor, cobalt (Co2+).
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