14-3-3 protein

14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. 14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. More than 200 signaling proteins have been reported as 14-3-3 ligands.

14-3-3
Cartoon diagram of Human 14-3-3 protein beta PDB entry 2bq0
Identifiers
Symbol14-3-3
PfamPF00244
InterProIPR000308
SMART14_3_3
PROSITEPDOC00633
SCOP21a4o / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Elevated amounts of 14-3-3 proteins in cerebrospinal fluid may be a sign of Creutzfeldt–Jakob disease.

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