Zollinger-Ellison syndrome

Background
  • aka S-E syndrome
  • gastric neuroendocrine malignancy results in hypersecretion of hydrochloric acid by parietal cells
  • Associated with peptic ulcers and diarrhea
  • 60% malignant, only 20% resectable; 25% of gastrinoma patients have multiple endocrine neoplasia type I; >80% of gastrinomas found in gastrinoma triangle.

Clinical Features
  • Hematemesis
  • Chronic diarrhea
  • Postprandial abdominal pain
  • Nausea
  • Wheezes on auscultation
  • Evidence of malnourishment and decreased oral intake

Differential Diagnosis


Evaluation

Management


Disposition


See Also



References
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