Temazepam

Administration

Type: Benzodiazepine
Dosage Forms: Cap 7.5mg, 15mg, 22.5mg, 30mg
Routes of Administration: Oral
Common Trade Names: Restoril

Adult Dosing

Insomnia

15mg PO qhs
- Start 7.5mg PO qhs in elderly patients

Sleep terrors

15-30mg PO qhs

Pediatric Dosing

Safety/efficacy not established in pediatric patients

Special Populations

Pregnancy Rating

Consider alternatives during pregnancy
Risk of neonatal withdrawal symptoms and floppy infant syndrome

Lactation risk

May use low doses short-term when breastfeeding

Renal Dosing

Adult: No adjustment
Pediatric: Not defined

Hepatic Dosing

Adult: No adjustment
Pediatric: Not defined

Contraindications

Allergy to class/drug
Pregnancy
Avoid abrupt withdrawal with long term use

Adverse Reactions

Serious

Anaphylaxis, angioedema
Respiratory depression
Dependency
Seizure
Suicidality
Tachycardia, hypotension, syncope

Common

Drowsiness, fatigue
Dizziness
Anxiety, Amnesia, confusion
Disinhibition
Dystonia. Dysarthria, diplopia
Incontinence, constipation
Rash

Pharmacology

Half-life: 8.8h
Metabolism: Liver
Excretion: Urine 80-90%

Mechanism of Action

Binds to benzodiazepine receptors to enhance GABA effects

Comments

See Also

References

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