Parvovirus B19

Background
  • In children: causes Erythema infectiosum (Fifth disease)
  • In transplant patients on immunosuppressive drugs: causes RBC aplasia.
    • Short-lived, may not be discovered
    • Parvovirus only replicated in erythroid progenitor cells

Clinical Features
  • Erythema infectiosum (fifth disease)
  • Most contagious during the phase of active viral replication and viral shedding, which occurs approximately 5 to 10 days after exposure and usually lasts approximately 5 days
  • Complications

Differential Diagnosis

Evaluation
  • Diagnosis is clinical usually through clinical presentation
  • IgM testing is recommended for immunocompromised patients.

Management
  • Parvovirus is usually self-limiting and requires no further treatment.
  • Management should be targeted at reducing symptoms, such as using anti-inflammatory medications for arthropathy or performing transfusions for aplastic anemia.

References
  • Fish RM, Massad MG. The Transplant Patient. In: Tintinalli JE, Stapczynski J, Ma O, Cline DM, Cydulka RK, Meckler GD, T. eds. Tintinalli's Emergency Medicine: A Comprehensive Study Guide. New York, NY: McGraw-Hill; 2011.
  • Place R, Lagoc AT, Mayer TA, Lawlor CJ. Oncology and Hematology Emergencies in Children. In: Tintinalli JE, Stapczynski J, Ma O, Cline DM, Cydulka RK, Meckler GD, T. eds. Tintinalli's Emergency Medicine: A Comprehensive Study Guide. New York, NY: McGraw-Hill; 2011
    This article is issued from Wikem. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.