Doxapram

Administration
  • Type: Respiratory Stimulator
  • Dosage Forms: INJ
  • Routes of Administration: IV
  • Common Trade Names: Dopram

Adult Dosing

Respiratory depression, postanesthesia
  • Intermittent Injection
    • 0.5-1 mg/kg IV q5min prn
      • Max: 1.5 mg/kg/single dose, 2 mg/kg/total dose, 3g/24h
  • Intermittent infusion
    • 0.5-1 mg/kg IV
      • Max: 4 mg/kg/dose, 3 g/24h

CNS depression, drug-induced
  • Intermittent Injection
    • 1-2 mg/kg IV q1-2h prn
  • Intermittent infusion
    • 1-3 mg/kg/h IV up to 2h

Acute hypercapnia, COPD-assoc.
  • 1-3 mg/min IV up to 2h

Pediatric Dosing

Respiratory depression, postanesthesia
  • Intermittent Injection
    • 0.5-1 mg/kg IV q5min prn
      • Max: 1.5 mg/kg/single dose, 2 mg/kg/total dose, 3g/24h
  • Intermittent infusion
    • 0.5-1 mg/kg IV
      • Max: 4 mg/kg/dose, 3 g/24h

CNS depression, drug-induced
  • Intermittent Injection
    • 1-2 mg/kg IV q1-2h prn
  • Intermittent infusion
    • 1-3 mg/kg/h IV up to 2h

Special Populations

Renal Dosing
  • Adult: Caution advised in significant impairment
  • Pediatric: Caution advised in significant impairment

Hepatic Dosing
  • Adult: Caution advised in significant impairment
  • Pediatric: Caution advised in significant impairment

Contraindications
  • Allergy to class/drug
  • Concurrent mechanical ventilation
  • Mechanical disorders of ventilation
  • Seizure disorder
  • Pulmonary embolism
  • Head injury
  • Stroke
  • Cerebral edema
  • Cardiovascular impairment, Heart failure, HTN

Adverse Reactions

Serious
  • Bronchospasm, laryngospasm
  • Arrhythmia
  • HTN
  • Seizure
  • Hallucinations
  • Hemolysis with rapid infusion

Common
  • Fever, flushing, diaphoresis
  • Pruritis, parasthesia
  • Mydriasis
  • Hallucination
  • Headache, dizziness
  • Hyperactivity, involuntary movements, muscle spasms
  • Seizure
  • Dyspnea, cough, hyperventilation, tachypnea
  • Phlebitis
  • Diarrhea, Urinary incontinence, urinary retention

Pharmacology
  • Half-life: 3.4h
  • Metabolism: Liver
  • Excretion: Urine (<5% unchanged)

Mechanism of Action
  • Acts on peripheral carotid chemoreceptors to stimulate respiration

Comments


See Also


References
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