Buspirone

Administration
  • Type: Anxiolytic
  • Dosage Forms:
  • Routes of Administration: PO
  • Common Trade Names: Buspar

Adult Dosing
  • 10-60mg/day divided q8-12h

Pediatric Dosing
  • Preadolescent: 2.5-5 mg PO daily
  • Adolescent: as adult

Special Populations

Pregnancy Rating
  • Category B

Lactation risk
  • Excretion in milk unknown/not recommended

Renal Dosing
  • Not recommended in severe renal impairment

Hepatic Dosing
  • Not recommended in severe hepatic impairment

Contraindications
  • Allergy to class/drug
  • Concomitant MAOI use
  • Severe renal/hepatic impairment

Adverse Reactions

Serious
  • Allergic reaction
  • Heart failure
  • Suicidal ideation
  • Increased ocular pressure
  • Dystonia

Common
  • Dizziness, weakness
  • Headache
  • Drowsiness, confusion, insomnia, nervousness, dream disturbance, akathisia
  • Blurred vision, visual disturbances, photophobia
  • Numbness, paresthesia
  • Tremor
  • Tinnitus
  • Nausea, diarrhea, anorexia
  • Myalgia
  • Rash
  • Nasal congestion, sore throat
  • Nonspecific chest pain
  • Bruising
  • Galactorrhea, menstrual irregularity, alopecia
  • Syncope
  • Eosinophilia
  • Edema
  • Enuresis
  • Rectal bleeding

Pharmacology
  • Half-life: 2-3h
  • Metabolism: Hepatic
  • Excretion: Urinary and in feces

Mechanism of Action
  • Unclear exact mechanism; high affinity for serotonin 5HT1A and 5HT2 receptors and moderate affinity for dopamine D2 receptors. No effect on benzodiazepine GABA receptors

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References
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