Allergic transfusion reaction
Background
- Occurs due to immune response to plasma proteins
- Reaction severity not dose-related
- Most frequently occurs with platelet transfusions
Clinical Features
- Symptoms range from urticaria/pruritus to bronchospasm, wheezing, anaphylaxis (rare)
Differential Diagnosis
Transfusion Reaction Types
- Acute
- Intravascular hemolytic tranfusion reaction
- Febrile nonhemolytic tranfusion reaction
- Allergic tranfusion reaction
- Transfusion-associated circulatory overload (TACO)
- Transfusion-related acute lung injury (TRALI)
- Transfusion-associated graft-versus-host disease
- Fluid overload
- Sepsis
- Delayed
- Extravascular hemolytic tranfusion reaction
- Graft-vs-host disease
- Transfusion infections
Acute allergic reaction
- Allergic reaction/urticaria
- Anaphylaxis
- Angioedema
- Anxiety attack
- Asthma exacerbation
- Carcinoid syndrome
- Cold urticaria
- Contrast induced allergic reaction
- Scombroid
- Shock
- Transfusion reaction
Evaluation
- May need to rule out hemolysis - see transfusion reaction
Management
- Stop transfusion until able to evaluate severity of allergic reaction
- Give diphenhydramine
- further treatment for anaphylaxis if needed
- Restart transfusion if symptoms are mild
See Also
- Transfusion reaction
- Acute allergic reaction
References
This article is issued from Wikem. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.