Assuming that your 50 million row table includes duplicates (perhaps that is part of the problem), and assuming SQL Server (the syntax may change but the concept is similar on most RDBMSes), another option is to store domains in a lookup table, e.g.
CREATE TABLE dbo.Domains
(
DomainID INT IDENTITY(1,1) PRIMARY KEY,
DomainName VARCHAR(255) NOT NULL
);
CREATE UNIQUE INDEX dn ON dbo.Domains(DomainName);
When you load new data, check if any of the domain names are new - and insert those into the Domains table. Then in your big table, you just include the DomainID. Not only will this keep your 50 million row table much smaller, it will also make lookups like this much more efficient.
SELECT * -- please specify column names
FROM dbo.tblDomainResults AS dr
INNER JOIN dbo.Domains AS d
ON dr.DomainID = d.DomainID
WHERE d.DomainName LIKE '%lifeis%';
Of course except on the tiniest of tables, it will always help to avoid LIKE clauses with a leading wildcard.