I'm not seeing that can take excel data directly to Data Lake. You might need to convert into CSV/TSV/Json or other formats before loading into Data Lake.
Formats Supported by Redshift Spectrum:
http://docs.aws.amazon.com/redshift/latest/dg/c-spectrum-data-files.html -- Again I don't see Excel as of now.
Athena Supported File Formats:
http://docs.aws.amazon.com/athena/latest/ug/supported-formats.html -- I don't see Excel also not supported here.
You need to upload the files to S3 either to Use Athena or Redshift Spectrum or even Redshift storage itself.
Uploading Files to S3:
If you have bigger files, you need to use S3 multipart upload to upload quicker. If you want more speed, you need to use S3 accelerator to upload your files.
Querying Big Data with Athena:
You can create external tables with Athena from S3 locations. Once you create external tables, use Athena Sql reference to query your data.
http://docs.aws.amazon.com/athena/latest/ug/language-reference.html
Querying Big Data with Redshift Spectrum:
Similar to Athena, you can create external tables with Redshift. Start querying those tables and get the results on Redshift.
Redshift has lot of commercial tools, I use SQL Workbench. It is free open source and rock solid, supported by AWS.
SQL WorkBench: http://www.sql-workbench.net/
Connecting your WorkBench to Redshift: http://docs.aws.amazon.com/redshift/latest/mgmt/connecting-using-workbench.html
Copying data to Redshift:
Also if you want to take the data storage to Redshift, you can use the copy command to pull the data from S3 and its gets loaded to Redshift.
Copy Command Examples:
http://docs.aws.amazon.com/redshift/latest/dg/r_COPY_command_examples.html
Redshift Cluster Size and Number of Nodes:
Before creating Redshift Cluster, check for required size and number of nodes needed. More number of nodes gets query parallely running. One more important factor is how well your data is distributed. (Distribution key and Sort keys)
I have a very good experience with Redshift, getting up to the speed might take sometime.
Hope it helps.